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apalutamide will minimize the extent or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with prescription drugs which have been CYP3A4 substrates may end up in reduce publicity to these prescription drugs.If you take codeine as a li